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WebJan 1, 2014 · Since baseline latencies vary between animals, this formula accommodates individual differences in response to the nociceptive stimulus. The tail-withdrawal test (Janssen et al. 1963) is a modification of the tail-flick test.In this procedure, mice or rats are gently restrained, and their tail is placed into a water bath maintained at temperatures … WebThe hot plate test is a test of the pain response in animals, similar to the tail flick test.Both hot plate and tail-flick methods are used generally for centrally acting analgesic, while peripherally acting drugs are ineffective in these tests but sensitive to acetic acid-induced writhing test. The hot plate test is used in basic pain research and in testing the … severance for termination with cause
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