Tfrc and ferroptosis
Web12 Apr 2024 · Ferroptosis combined with immunity shows a pivotal role in a variety of tumors, which provides new opportunities to detect and treat breast cancer. Methods: Our … WebFerroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues.
Tfrc and ferroptosis
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Web23 Aug 2024 · Prediction of prognosis of ferroptosis related genes in EAC and ESCC. Zhu et al. [] examined genes related to ferroptosis in patients with EAC using The Cancer Genome Atlas (TCGA) database, and they found the ferroptosis-related genes were mainly associated with lipid metabolism, iron metabolism, energy metabolism and anti-oxidative … Web10 Aug 2024 · Intracellular iron homeostasis is a highly regulated process (see Chap. 3) that depends on a number of proteins involved in iron transport (transferrin receptor (TFRC), transferrin (TF), ferroportin (FPN)) and storage (ferritin) (Pantopoulos et al. 2012 ).
Web14 Feb 2024 · Ferroptosis is regulated by multiples of mechanisms such as system Xc−mechanism, glutathione peroxidase 4 (GPX4) mechanism, iron metabolism and lipid …
Web12 Aug 2024 · Nevertheless, several important ferroptosis driver genes, such as ASCL4 and TFRC, were upregulated in the patient samples (Additional file 3: Fig. S3D). Acyl-CoA … Web5 Nov 2024 · Transferrin (Tf) with two ferric iron (Fe 3+) combines with TFRC and then enters the cell through endocytosis. In endosomes, ferric iron is reduced to ferrous iron …
WebFerroptosis is a new mode of cell death discovered in recent years, which emerged after the discovery that a small molecule compound, erastin and RSL-3, could induce a unique form …
Web19 Oct 2024 · In contrast, in breast tumors YAP has been shown to promote ferroptosis. Under cell–cell contact conditions, E-cadherin suppresses ferroptosis by activating NF2 … how to setup logitech wheelWeb18 Oct 2024 · Ferroptosis is a new form of regulated cell death, which is mediated by intracellular iron. Although it is reported that bavachin has antitumour effects on several tumour cells and prompts the reactive oxygen species (ROS) generation, it is unclear whether ferroptosis can be induced by bavachin in osteosarcoma (OS) cells. notice of posting jury fees los angelesWeb6 Jun 2024 · Alternatively, LTF may promote iron absorption and subsequent ferroptosis in a TFRC-independent manner []. After iron absorption, a STEAP3 metalloreductase … how to setup logitech rudder pedalsWeb6 Jun 2024 · The aim of the present study was to clarify the activation of ferroptosis in different breast cancer cells by sulfasalazine (SAS) and to explore the relationship … notice of posting undertaking caWebThe regulation of ferritin and iron metabolism is essential in the ferroptosis mechanism. 25 TFRC is required for the uptake of the transferrin-iron complex into cells. WB showed that TFRC expression was significantly increased in the HALI group (P<0.05). Ferritin is an essential protein used to store iron ions in cells. how to setup logitech powerplayWebThe mRNA and protein expression levels of key ferroptosis-related markers (GPX4, TFRC, FTL, and FTH1) indicated that ferroptosis was suppressed by the overexpression of … notice of postpetition mortgage fees formWebFerroptosis is an RCD triggered by oxidative stress in the intracellular microenvironment, which typically involves iron metabolism and lipid metabolism, ultimately causing iron-dependent peroxidation and oxidative cell death. Most classical ferroptosis inducers such as Erastin and RSL3 are also inhibitors of the cellular antioxidant system, 22 ... how to setup logitech steering wheel